Ken Kishida, PhD
Description of Work
Humans make choices in everything we do. These choices result from biological mechanisms in the brain. My research uses integrative neuroscience approaches to investigate function and dysfunction in the human brain. I utilize invasive and non-invasive techniques, including functional magnetic resonance imaging (fMRI) and fast-scan cyclic voltammetry, to measure physiological activity while individuals are actively engaged in decision-making processes. These and other tools are ripe for developing new insights into the function of the human nervous system.
Measurements of Dopamine Release in Humans
I have recently used fast-scan cyclic voltammetry to make the first sub-second measurements of dopamine release in a human brain during an active decision-making task (Kishida et al., 2011). These measurements took place in a patient undergoing deep-brain stimulation electrode implantation for the treatment of Parkinson’s disease. Currently, I am using this newly developed technology to generate unprecedented insight into the function of dopamine systems in humans.
Biomarkers for Autism Spectrum Disorders
Using functional magnetic resonance imaging and neuroeconomic approaches, I have investigated brain responses associated with social exchange and perspective taking in healthy individuals and volunteers diagnosed with ASD (Chiu et al., 2008, Kishida et al., 2012). Currently I am using a paradigm that utilizes rapid fMRI protocols, experimentally determined regions of interest, and multidimensional classification procedures to identify individuals diagnosed with ASD with good specificity and sensitivity.
Education and Training
- Baylor College of Medicine: Ph.D., Neuroscience
- Baylor College of Medicine: Postdoctoral fellowship
- Kishida, K.T., and Montague, P.R. (2013). Economic probes of mental function and the extraction of computational phenotypes. Journal of Economic Behavior & Organization 94, 234–41.
- Kishida, K.T., Yang, D., Quartz, K.H., Quartz, S.R., and Montague, P.R. (2012). Implicit signals in small group settings and their impact on the expression of cognitive capacity and associated brain responses. Phil. Trans. R. Soc. B 2012(367), 704-16.
- Kishida, K.T. (2012). A computational approach to “free will” constrained by the games we play. Frontiers in Integrative Neuroscience.
- Kishida KT, Li J, Schwind J, Montague PR. (2012). New approaches to investigating social gestures in autism spectrum disorder. Journal of Neurodevelopmental Disorders 4(14).
- Kishida, K.T., Sandberg, S.S., Lohrenz, T., Comair, Y.G., Saez, I.G., Phillips, P.E.M., and Montague, P.R. (2011). Sub-second dopamine detection in human striatum. PLoS ONE 6(8), e23291.
- Kishida KT, King-Casas B, Montague PR. (2010). Neuroeconomic approaches to mental disorders. Neuron 67(4), 543-54.
- Chiu PH, Kayali MA, Kishida KT, Tomlin D, Klinger LG, Klinger MR, Montague PR. (2008). Self responses along cingulate cortex reveal quantitative neural phenotype for high-functioning autism. Neuron 57(3), 463-73.
- Kishida KT, Klann E. (2007). Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal 9(2), 233-44.
- Kishida KT, Hoeffer CA, Hu D, Pao M, Holland SM, Klann E. (2006). Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Mol Cell Biol 26(15), 5908-20.
- Kishida KT, Pao M, Holland SM, Klann E. (2005). NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1. J Neurochem 94(2), 299-306.