Robert Gourdie, PhD
Professor, Virginia Tech Carilion Research Institute
Commonwealth Research Commercialization Fund Eminent Scholar in Heart Regenerative Medicine Research, Virginia Tech Carilion Research Institute
Director, Center for Heart and Regenerative Medicine Research, Virginia Tech Carilion Research Institute
Professor, Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences
Professor of Emergency Medicine, Virginia Tech Carilion School of Medicine
Director of Emergency Medicine Research, Carilion Clinic
Research Program Summary
The research of the lab is on the subunit proteins of gap junctions—connexins. Our work encompasses both basic and practical/translational aspects. In basic research we study cellular and molecular mechanisms of the carboxyl terminal domain of Cx43 in regulating gap junction remodeling and electrical conduction in the normal and arrhythmic heart. In our more practically oriented work, we focus on Cx43 assignments in wound healing, scarring, and regeneration. The lab is developing a platform of drugs targeting Cx43 function. The first of our candidates is a mimetic of the carboxyl terminus of Cx43(aCT1). Based on our results in skin and heart, we have been granted three patents in regenerative medicine. The lab currently has another five patents pending on small molecules and stem cell technologies. One of our technologies is now in phase II clinical trials.
For a full listing of Dr. Gourdie's publications, visit PubMed.
Education and Training
- University College London: Postdoctoral fellowship, Developmental Biology and Anatomy
- University of Auckland: M.S.
- University of Canterbury: Ph.D., Biophysics
Medical University of South Carolina Professor, Board of Trustees' Eminent Scholar Co-Director, Cardiovascular Developmental Biology Center
Clemson University Adjunct Professor, Bioengineering
Awards and Honors
- Commonwealth Research Commercialization Fund Scholar, beginning 2012
- MUSC Board of Trustees’ Eminent Scholar, 2008–2012
- Prizewinner, Charleston Business Journal Innovator, 2006
- National Science Foundation Early Career Scholar, 1998
- Developing Scholar Award, MUSC Health Sciences Foundation, 1997
- Basil O’Connor Scholar, March of Dimes Birth Defects Foundation, 1996
- Gourdie RG, Myers TA. (2013). Methods in Molecular Biology. Humana Press.
- Rhett JM, Veeraraghavahan S, Poelzing S, Gourdie RG. (2013). The perinexus: Sign-post on the path to a new model of cardiac conduction? Trends in Cardiovascular Medicine.
- Palatinus JA, Rhett JM, Gourdie RG. (2012). The connexin43 carboxyl terminus and cardiac gap junction organization. Biochimica et Biophysica Acta, in press.
- Rhett JM, Jourdan J, Gourdie RG. (2011). Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1. Molecular Biology of the Cell 22(9), 1516-28.
- O'Quinn MP, Palatinus JA, Harris BS, Hewett KW, Gourdie RG. (2011). A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circulation Research 108(6), 704-15.
- Ghatnekar GS*, O'Quinn MP*, Jourdan LJ, Gurjarpadhye AA*, Draughn RL, Gourdie RG. (2009). Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding. Regenerative Medicine 4(2), 205-23.
- Hunter AW, Barker RJ, Zhu C, Gourdie RG. (2006). Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Molecular Biology of the Cell 16(12), 5686-98.