Research Areas in Immunity and Infection

Autoimmunity

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Biological Machinery

When cells miscommunicate during development, the results can be catastrophic. Children and adults alike end up with a host of diseases, including cancer and heart defects.

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Immune System

The formation of the immune system is entirely dependent on the ability of numerous cell types to arise from a common progenitor. Developmental transcription factors are necessary for regulating the cell-type-specific gene expression patterns dictating the phenotype of each these unique cells. Unfortunately, mutations in these key factors often lead to their improper function, resulting in cancer and autoimmune disease. It is critically important, therefore, to understand the molecular mechanisms by which transcription factors direct cellspecific gene expression profiles.

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Immunological Memory

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