Harry Dorn, Ph.D.
Professor, Virginia Tech Carilion Research Institute
Professor, Chemistry, College of Science at Virginia Tech
Professor of Radiology, Virginia Tech Carilion School of Medicine
A.C. Lilly Faculty Fellow of Nanoscience, Virginia Tech
For nearly 40 years, Harry Dorn has made pioneering developments in joining high-performance liquid chromatography with nuclear magnetic resonance to form a technique that has since become an important tool in the pharmaceutical and biomedical fields. His laboratory has also initiated a second research area involving electron paramagnetic resonance and dynamic nuclear polarization. This work has led to new approaches for next-generation magnetic resonance imaging instruments. In the early 1990s, the Dorn Laboratory began a new area of research involving the synthesis, separation, and functionalization of the newly discovered carbonaceous nanomaterials, nanotubes, fullerenes, and metal-encapsulated fullerenes, or endohedral metallofullerenes. More recently, the Dorn Laboratory reported a remotely new class of radiolabeled fullerenes.
Dorn received his doctorate in physical and organic chemistry from the University of California in 1974, at which time he joined the Virginia Tech team. In 1992, he received the IBM Research Division Award and in 2006 he received the Virginia Tech Alumni Award for Research Excellence. He was honored to speak at the Naff Symposium, University of Kentucky in 2008. In 2009, Dorn presented the Plenary Lecture at the 37th Fullerene-Nanotube General Symposium in Tsukuba, Japan. In 2014, Dorn was reappointed the A.C. Lilly Faculty Fellow of Nanoscience at Virginia Tech.
In addition to his positions at the Virginia Tech Carilion Research Institute, Dorn directs the Carbonaceous Nanomaterials Center at Virginia Tech.
For a more complete listing of Harry Dorn's publications, visit PubMed.
Education and Training
- Colorado State University: Postdoctoral Fellowship
- University of California Davis: PhD, Physical and Organic Chemistry
- University of California Santa Barbara: BS, Chemistry
Awards and Honors
- A.C. Lilly Faculty Fellow of Nanoscience, Virginia Tech, 2013 and 2010
- John Schug Research Award, Department of Chemistry, Virginia Tech, 2007
- Scholar of the Week, Virginia Tech, 2006
- Alumni Award for Research Excellence, Virginia Tech, 2006
- Li T, Murphy S, Kiselev B, Bakshi KS, Zhang J, Eltahir A, Zhang Y, Chen Y, Zhu J, Davis RM, Madsen LA, Morris JR, Karolyi DR, LaConte SM, Sheng Z, Dorn HC. (2015). A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells. Journal of the American Chemical Society 137(24): 7881-8.
- Luo J, Wilson JD, Zhang J, Hirsch JI, Dorn HC, Fatouros PP, Shultz MD. (2012). A dual PET/MR imaging nanoprobe: 124I labeled Gd3N@C80. Applied Sciences 2(2): 465-78.
- Fillmore HL, Shultz MD, Henderson SC, Cooper P, Broaddus WC, Chen ZJ, Shu CY, Zhang J, Ge J, Dorn HC, Corwin F, Hirsch JI, Wilson J, Fatouros PP. (2011). Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors. Nanomedicine 6(3): 449-58.
- Shultz MD, Wilson JD, Fuller CE, Zhang J, Dorn HC, Fatouros PP. (2011). Metallofullerene-based nanoplatform for brain tumor brachytherapy and longitudinal imaging in a murine orthotopic xenograft model. Radiology 261: 136-43.
- Whitney JR, Sarkar S, Zhang J, Do T, Young T, Manson MK, Campbell TA, Puretzky AA, Rouleau CM, More KL, Geohegan DB, Rylander CG, Dorn HC, Rylander MN. (2011). Single walled carbon nanohorns as photothermal cancer agents. Laser in Surgery and Medicine 43(1): 43-51.
- Shultz MD, Duchamp JC, Wilson JD, Shu C, Ge J, Zhang J, Gibson HW, Fillmore HL, Hirsch JI, Dorn HC, Fatouros PP. (2010). Encapsulation of a radiolabeled cluster Inside a fullerene cage, 177LuxLu(3-x)N@C80: An interleukin-13-conjugated radiolabeled metallofullerene platform. Journal of the American Chemical Society 132(14): 4980-1.
- Zhang J, Fatouros PP, Shu C, Reid J, Owens LS, Cai T, Gibson HW, Long GL, Corwin FD, Chen ZJ, Dorn HC. (2010). High relaxivity trimetallic nitride (Gd3N) metallofullerene MRI contrast agents with optimized functionality. Bioconjugate Chemistry 24(4): 610-5.
- Zhang J, Ge J, Shultz MD, Chung E, Singh G, Shu C, Fatouros PP, Henderson SC, Corwin FD, Geohegan DB, Puretzky AA, Rouleau CM, More K, Rylander C, Rylander MN, Gibson HW, Dorn HC. (2010). In vitro and in vivo studies of single-walled carbon nanohorns with encapsulated metallofullerenes and exohedrally functionalized quantum dots. NanoLetters 10(8): 2843-8.
- Shu C, Corwin FD, Zhang J, Chen Z, Reid JE, Sun M, Xu W, Sim JH, Wang C, Fatouros PP, Esker AR, Gibson HW, Dorn HC. (2009). Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivity. Bioconjugate Chemistry 20(6): 1186-93.
- Shu CY, Ma XY, Zhang JF, Corwin FD, Sim JH, Zhang EY, Dorn HC, Gibson HW, Fatouros PP, Wang CR, Fang XH. (2008). Conjugation of a water-soluble gadolinium endohedral fulleride with an antibody as a magnetic resonance imaging contrast agent. Bioconjugate Chemistry 9(3): 651-5.