Hodja Kalikulov

Hodja Kalikulov, Ph.D.

Research Assistant Professor

Contact

Office phone: 540-526-2054

Email address: hodja52@vtc.vt.edu

Synaptic plasticity is widely considered to be a cellular mechanism underlying learning and memory. Intracellular calcium signaling plays a key role in the regulation of synaptic plasticity in many brains system. We previously showed that pairing of pre- and postsynaptic activity in layer 2/3 pyramidal neurons in visual cortex at a fixed temporal delay produces variable plasticity outcomes - long-term potentiation (LTP), long-term depression (LTD), or no change (NC) - in different cells. The major goal of my research is to determine whether these different plasticity outcomes are a function of the individual cell’s intracellular calcium signaling in response to the pairings.

Education and Training

  • Institute of Biochemistry, Academy of Sciences of Uzbekistan: Ph.D. , Biophysics
  • Baylor College of Medicine: Postdoctoral fellowship , Neuroscience

Selected Publications

Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjević K, Noebels JL, Costa-Mattioli M. (2011). Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition . Cell 147 (6) : 1384-96.

Ismailov I, Kalikulov D, Inoue T, Friedlander MJ. (2004). The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression . J Neurosci 24 (44) : 9847-61.

Kalikulov D, Ayar A, Nuritova F, Frenguelli BG, McClelland Martin DJ, Davidson I, Scott RH. (2001). Venom from Anemesia species of spider modulates high voltage-activated Ca2+ currents from rat cultured sensory neurones and excitatory postsynaptic currents from rat hippocampal slices . Cell Calcium 30 (3) : 212-21.