Leslie LaConte

Leslie LaConte, Ph.D.

Assistant Dean for Research, Virginia Tech Carilion School of Medicine

Research Assistant Professor, Virginia Tech Carilion Research Institute

Assistant Professor of Biomedical Sciences, Virginia Tech Carilion School of Medicine

Dr. Leslie LaConte's research interests lie in the field of structural biology. Working with Dr. Konark Mukherjee, she is currently investigating proteins found in the presynaptic active zone of neurons. Active zone proteins are critically important for neurotransmission and plasticity, and mutations in such proteins are associated with disorders such as X-linked mental retardation and autism. Although many of these proteins have been identified, their roles in both signaling and scaffolding remain to be clearly determined. By studying interactions between these proteins in vitro, in cell culture, and in organisms such as Drosophila and mice, Dr. LaConte hopes to contribute to the development of a more complete picture of synaptic transmission. Techniques to be used in the study of such interactions include immunoprecipitation, molecular modeling, site-directed mutagenesis, targeted disruption by small molecules, and fluorescence spectroscopy.

In addition to her research, Dr. LaConte devotes time to teaching biochemistry and facilitating in the Virginia Tech Carilion School of Medicine.

Education and Training

  • Georgia Institute of Technology: Postdoctoral Fellowship
  • University of Minnesota: Ph.D., Biochemistry

Selected Publications

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