Leslie LaConte, Ph.D.
Assistant Dean for Research, Virginia Tech Carilion School of Medicine
Research Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor of Biomedical Sciences, Virginia Tech Carilion School of Medicine
Dr. Leslie LaConte's research interests lie in the field of structural biology. Working with Dr. Konark Mukherjee, she is currently investigating the impact that missense mutations have on the structure and function of CASK, a putatively synaptic protein associated with microcephaly and developmental delay, using both computational and cell biological tools.
In addition to her own research, Dr. LaConte oversees medical student research and teaches cell biology in the Virginia Tech Carilion School of Medicine.
Education and Training
- Georgia Institute of Technology: Postdoctoral Fellowship
- University of Minnesota: Ph.D., Biochemistry
- McKell A, LaConte LEW, McDonald SM. (2017). Temperature-sensitive lesion in the N-terminal domain of the rotavirus polymerase affects its intracellular localization and enzymatic activity. Journal of Virology.
- LaConte LE, Chavan V, Liang C, Willis J, Schönhense EM, Schoch S, Mukherjee K. (2016). CASK stabilizes neurexin and links it to liprin-a in a neuronal activity-dependent manner. Cell Mol Life Sci: [Epub ahead print] doi:10.1371/journal.pone.0088276.
- LaConte LEW, Chavan V, Mukherjee K. (2014). Identification and glycerol-induced correction of misfolding mutations in the X-linked mental retardation gene CASK. PLOS ONE.
- LaConte L, Mukherjee K. (2013). Structural constraints and functional divergences in CASK evolution. Biochem Soc Trans 41(4): 1017-22.
- LaConte L, Johnson TA, Vari RC, Friedlander MJ. (2013). Research immersion at the Virginia Tech Carilion School of Medicine – an integrated curriculum producing scientist physicians for the future of healthcare. Med Sci Educ 23: 122-134.