Rengasayee (Sai) Veeraraghavan, Ph.D.
Research Assistant Professor
My primary research interest is the structural basis of cardiac conduction. Specifically, I am investigating the precise ultrastructural organization of ion channels and gap junctions within the intercalated disk of cardiac myocytes and in the role of such organization in mediating action potential propagation between myocytes. Understanding these structure function relationships is vital to the development of novel therapies to prevent conduction disturbance, which are a major cause of potentially lethal cardiac arrhythmias. I will be working in Dr. Robert Gourdie's laboratory using a wide array of cutting-edge microscopy techniques to investigate macromolecular complexes of proteins directly involved in cardiac conduction as well as structural proteins that help stabilize the specific membrane microdomains. This structural knowledge will then serve as a basis for functional studies of cardiac conduction, where the precise role of these macromolecular complexes will be investigated.
Education and Training
- University of Utah: Ph.D., Bioenginering
- Anna University: B.S., Chemical Engineering
- Post-doctoral Research Fellow, University of Utah, UT (2011-2012)
- Graduate Research Assistant, University of Utah, UT (2005-2011)
Awards and Honors
- Member, Heart Rhythm Society (since 2006)
- Member, American Heart Association (since 2006)
- Member, Cardiac Electrophysiology Society (2006)
- Member, Biophysical Society Member (since 2010)
- Veeraraghavan R, Gourdie RG. (2016). Stochastic Optical Reconstruction Microscopy-based Relative Localization Analysis (STORM-RLA) for Quantitative Nanoscale Assessment of Spatial Protein Organization. Mol Biol Cell.
- Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Beleyvich AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S. (2016). Neuronal Na+ Channels Are Integral Components of Pro-Arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation. JACC: Basic to Translational Science.
- Veeraraghavan R, Lin J, Keener JP, Gourdie RG, Poelzing S. (2016). Potassium Channels in the Cx43 Gap Junction Perinexus Modulate Ephaptic Coupling: An Experimental and Modeling Study. Pflugers Archiv.
- Veeraraghavan R, Lin J, Hoeker GS, Keener JP*, Gourdie RG*, Poelzing S*. (2015). Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study. Pflugers Archive - European Journal of Physiology.
- Radwański PB, Brunello L, Veeraraghavan R, Ho H, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PM, Mohler PJ, Bridge JH, Poelzing S, Györke S. (2014). Neuronal Na+ Channel Blockade Suppresses Arrhythmogenic Diastolic Ca2+ Release. Cardiovascular Research.
- Veeraraghavan R, Poelzing S, Gourdie RG. (2014). Novel ligands for zipping and unzipping the intercalated disk: today's experimental tools, tomorrow's therapies? Cardiovasc Res 104(2), 229-30.
- Veeraraghavan R, Gourdie RG, Poelzing S. (2014). Mechanisms of Cardiac Conduction: A History of Revisions. Am J Physiol Heart Circ Physiol 306(5), H619-27.
- Veeraraghavan R, Poelzing S, Gourdie RG. (2014). Old Cogs, New Tricks: A Scaffolding Role For Connexin43 And A Junctional Role For Sodium Channels?. FEBS Lett.
- Rhett JM, Veeraraghavahan S, Poelzing S, Gourdie RG. (2013). The perinexus: Sign-post on the path to a new model of cardiac conduction? Trends in Cardiovascular Medicine.
- Radwański P, Veeraraghavan R, Poelzing S. (2012). Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in guinea pig model of andersen-tawil syndrome. Heart Rhythm 7(10), 1428-35.