Susan Campbell, Ph.D.
Research Assistant Professor
The focus of Dr. Campbell’s research is to understand mechanisms involved in the development of tumor-associated seizures in the pediatric population and to examine molecular markers that could serve as therapeutic targets to treat pediatric epilepsy. Seizures are a particularly important problem in children suffering from brain tumors, as each seizure impairs normal cognitive development. Surprisingly, seizures in pediatric brain tumor patients are essentially understudied. This is at least partially due to a lack of good models for pediatric gliomas that recapitulates tumor associated epilepsy. The focus of Dr. Campbell’s research is to understand how interactions between pediatric tumor cells and the brain environment in which they grow influences tumor growth, peritumoral hyperexcitability and seizure susceptibility.
For a full listing of Dr. Campbell's publications, visit PubMed.
Education and Training
- University of Alabama at Birmingham: PhD, Neurobiology
- State University of New York at Binghamton: BS, Psychobiology
- University of Alabama at Birmingham
Instructor, Department of Neurobiology
Research Associate, Laboratory of Dr. Harold Sontheimer, Department of Neurobiology Postdoctoral Fellow, Laboratory of Dr. Harold Sontheimer, Department of Neurobiology Postdoctoral Fellow, Laboratory of Dr. David Sweatt, Department of Neurobiology Graduate Student, Laboratory of Dr. John J. Hablitz, Department of Neurobiology
Awards and Honors
- Training Program in Brain Tumor Biology, 2010-2012
- Robert SM, Buckingham SC, Campbell SL, Robel S, Holt KT, Ogunrinu-Babarinde T, Warren PP, White DM, Reid MA, Eschbacher JM, Berens ME, Lahti AC, Nabors LB, Sontheimer H. (2015). SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma. Science Translational Medicine 7(289).
- Robel S, Buckingham SC, Boni JL, Campbell SL, Danbolt NC, Riedmann T, Sutor B, Sontheimer H. (2015). Reactive astrogliosis causes the development of spontaneous seizures. Journal of Neuroscience 35(8), 3330-45.
- Campbell SL, Robel S, Cuddapah VA, Robert S, Buckingham SC, Kahle KT, Sontheimer H. (2015). GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia 63(1), 23-36.
- Campbell SL, Hablitz JJ, Olsen ML. (2014). Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia. Frontiers in Cellular Neuroscience 8, 425.