People Related To Synaptic Function Research

Shannon Farris, Ph.D.

Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor, VTCRI Developmental and Translational Neurobiology Center
Assistant Professor, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine

Michael Fox, Ph.D.

Associate Professor, Virginia Tech Carilion Research Institute
Director, Center for Developmental and Translational Neurobiology
Associate Professor, Biological Sciences, College of Science, Virginia Tech
Associate Professor, Department of Pediatrics, Virginia Tech Carilion School of Medicine

Michael J. Friedlander, Ph.D.

Executive Director, Virginia Tech Carilion Research Institute
Vice President for Health Sciences and Technology, Virginia Tech
Senior Dean for Research, Virginia Tech Carilion School of Medicine
Professor of Biological Sciences, College of Science, Virginia Tech
Professor, Department of Biomedical Engineering and Mechanics, College of Engineering, Virginia Tech
Professor of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine

Stephen M LaConte, Ph.D.

Associate Professor, Virginia Tech Carilion Research Institute
Associate Professor, Department of Biomedical Engineering and Mechanics, College of Engineering, Virginia Tech
Associate Professor of Emergency Medicine, Virginia Tech Carilion School of Medicine

Alexei Morozov, Ph.D.

Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor, Department of Biomedical Engineering and Mechanics, College of Engineering, Virginia Tech
Assistant Professor of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine

Konark Mukherjee, Ph.D.

Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor of Biological Sciences, College of Science, Virginia Tech
Assistant Professor of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine

Yuchin Albert Pan, Ph.D.

Associate Professor, Virginia Tech Carilion Research Institute
Commonwealth Center for Innovative Technology Eminent Research Scholar in Developmental Neuroscience, Virginia Tech Carilion Research Institute
Associate Professor, Health Sciences & Education, Office of the Provost, Virginia Tech

Stefanie Robel, Ph.D.

Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor, School of Neuroscience, College of Science, Virginia Tech
Assistant Professor, Basic Science Education, Virginia Tech Carilion School of Medicine

Harald Sontheimer, Ph.D.

Executive Director and Professor, School of Neuroscience, College of Science, Virginia Tech
Professor, Virginia Tech Carilion Research Institute
Director, VTCRI Center for Glial Biology in Health, Disease, and Cancer
I. D. Wilson Chair in the College of Science, Virginia Tech
Commonwealth Eminent Scholar in Cancer Research

Sharon A. Swanger, Ph.D.

Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor, VTCRI Developmental and Translational Neurobiology Center
Assistant Professor, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine

Gregorio Valdez, Ph.D.

Associate Professor, Virginia Tech Carilion Research Institute
Associate Professor, Biological Sciences, College of Science, Virginia Tech
Associate Professor of Internal Medicine, Virginia Tech Carilion School of Medicine

Events Related To Synaptic Function

Investigating Synaptic Dysfunction in Human Neuronal Models of Tauopathy

March 2, 2017, 10 a.m. at Virginia Tech Carilion Research Institute

Tara Tracy, Ph.D.


Research Scientist, J. David Gladstone Institutes, Gladstone Institute of Neurological Disease, Department of Neurology,
University of California, San Francisco

Special Seminars

Synaptic, Spiking and Vascular Cortical Maps of Sensory Stimulus Selectivity

Nov. 22, 2016, 1:25 p.m. at Virginia Tech Carilion Research Institute

Prakash Kara


Associate Professor, Neuroscience and Ophthalmology, Medical University of South Carolina; Clemson Bioengineering

Special Seminars

The Molecular Control of Synaptic Plasticity and Its Importance for Precision Neuroscience

Oct. 6, 2016, 3:45 p.m. at Virginia Tech Carilion Research Institute

Clive Bramham, M.D./Ph.D.


Professor of Neuroscience, Department of Biomedicine and KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Bergen, Norway

Virginia Nordic Precision Neuroscience Conference

The Role of Patterned Stimulation in Inducing Synaptic Plasticity in the Normal and Injured Brain

Oct. 6, 2016, 10:50 a.m. at Virginia Tech Carilion Research Institute

Michael J. Friedlander, Ph.D.


Vice President of Health Sciences and Technology, Virginia Tech; Executive Director, Virginia Tech Carilion Research Institute; and Senior Dean for Research, Virginia Tech Carilion School of Medicine

Virginia Nordic Precision Neuroscience Conference

Synaptic Biomarkers: Promise and Perils for Identifying and Using Them to Optimize Neuronal Health

Oct. 5, 2016, 3:10 p.m. at Virginia Tech Carilion Research Institute

Greg Valdez, Ph.D.


Assistant Professor, Virginia Tech Carilion Research Institute and Biological Sciences, College of Science, Virginia Tech

Virginia Nordic Precision Neuroscience Conference

Balancing Ultrastructural Synaptic Plasticity During Changes in Synapse Function

April 18, 2014, 11 a.m. at Virginia Tech Carilion Research Institute

Kristen Harris, PhD


Professor of Neurobiology, Center for Learning and Memory, Institute of Neuroscience, University of Texas

VTCRI Pioneers in Biomedical Research Program

Roles for Extracellular Matrix Molecules in Synaptic Targeting and Synaptic Differentiation

June 5, 2012, noon at Virginia Tech Carilion Research Institute

Michael Fox, PhD


Assistant Professor, Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia

Special Seminars

Synaptic Effects of Aging and ALS From Cellular Phenomena to Molecular Analysis

Aug. 16, 2011, 1 p.m. at Virginia Tech Carilion Research Institute

Gregorio Valdez, PhD


Postdoctoral Fellow, Department of Molecular and Cellular Biology and the Center for Brain Science, Harvard University

Special Seminars

Molecular mechanisms underlying synaptic dysfunction in Alzheimer's disease and Phelan-McDermid syndrome

May 20, 2011, noon at Virginia Tech Carilion Research Institute

Craig C. Garner, PhD


Professor, Department of Psychiatry and Behavioral Science, Co-Director, Center for Research and Treatment of Down Syndrome, Stanford University School of Medicine, Palo Alto, Calif.

VTCRI Maury Strauss Distinguished Public Lectures

Synaptic plasticity; the brain's response to experience

May 6, 2011, 4 p.m. at Virginia Tech Carilion Research Institute

Robert C. Malenka, PhD, MD


Pritzker Professor of Psychiatry and Behavioral Sciences, Co-Director, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Palo Alto, Calif.

VTCRI Maury Strauss Distinguished Public Lectures

Publications Related To Synaptic Function

Swanger SA, Vance KM, Acker TM, Zimmerman SS, DiRaddo JO, Myers SJ, Mosley CA, Summer SL, Menaldino DF, Liotta DC, Traynelis SF. (2018). A novel negative allosteric modulator selective for GluN2C/2D-containing NMDARs inhibits synaptic transmission in hippocampal interneurons. ACS Chemical Neuroscience 9(2): 306-19.

Helton T, Zhao M, Farris S, Dudek SM. (2018). Diversity of dendritic morphology and entorhinal cortex synaptic effectiveness in mouse CA2 pyramidal neurons. Hippocampus.

Pirbhoy PS, Farris S, Steward O. (2017). Synaptically-driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses vs. dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learning and Memory 24(8): 341-57.

Pirbhoy PS, Farris S, Steward O. (2016). Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains. Learning and Memory 23(6): 255-69.

Beier KT, Mundell NA, Pan YA, Cepko CL. (2016). Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors. Current Protocols in Neuroscience.

Chavan V, Willis J, Walker S, Clark H, Liu X, Srivastava S and Mukherjee K. (2015). Majority of central presynaptic terminals are ATP-enriched but devoid of mitochondria. PLoS One 10(4).

Chavan V, Willis J, Walker SK, Clark HR, Lui X, Fox MA, Srivastava S, Mukherjee K. (2015). Central presynaptic terminals are enriched in ATP but the majority lack mitochondria. PLoS ONE 10(4).

Mundell NA, Beier KT, Pan YA, Lapan SW, Aytürk AG, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL. (2015). Journal of Comparative Neurology.

Fitting S, Ignatowska-Jankowska BM, Bull C, Skoff RP, Lichtman AH, Wise LE, Fox MA, Su J, Medina AE, Krahe TE, Knapp PE, Guido W, Hauser KF. (2013). Synaptic dysfunction in the hippocampus accompanies learning and memory deficits in human immunodeficiency virus type-1 Tat transgenic mice. Biol Psychiatry 73(5): 443-53.

Samuel MA, Valdez G, Tapia JC, Lichtman JW, Sanes JR. (2012). Agrin and synaptic laminin are required to maintain adult neuromuscular junctions. PLoS One 7(10): e46663.

Subramanian J, Morozov A. (2011). Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. The Journal of Neuroscience 31(12): 4755-64.

Moran RJ, Symmonds M, Stephan KE, Friston KJ, Dolan RJ. (2011). An in vivo assay of synaptic function mediating human cognition. Current Biology 21(15): 1320-1325.

Carlson SS, Valdez G, Sanes JR. (2010). Presynaptic calcium channels and alpha3- integrins are complexed with synaptic cleft laminins, cytoskeletal elements and active zone components. Journal of Neurochemistry.

Mukherjee K ,Yang X, Gerber SH , Kwon HB , Ho A , Castillo P , Liu X , Südhof TC. (2010). Piccolo and Bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proc Natl Acad Sci USA 107(14): 6504-09.

Saez, I and Friedlander, MJ. (2009). Synaptic output of individual layer 4 neurons in guinea pig visual cortex. J. Neurosci 29: 4930-4944.

Pan B-X, Dong Y, Ito W, Yanagawa Y, Shigemoto R, Morozov A. (2009). Selective gating of glutamatergic inputs to excitatory neurons of amygdala by presynaptic GABAb receptor. Neuron 61(6): 917-29.

Proszynski TJ, Gingras J, Valdez G, Krzewski K, Sanes JR. (2009). Podosomes are present in a postsynaptic apparatus and participate in its maturation. Proceedings of the National Academy of Science 106: 18373-8.

Moran RJ, Stephan KE, Kiebel SJ, Rombach N, O'Connor WT, Murphy KJ, Reilly RB, Friston KJ. (2008). Bayesian estimation of synaptic physiology from the spectral responses of neural masses. Neuroimage 2(1): 272-84.

Lyckman AW, Horng S, Leamey CA, Tropea D, Watakabe A, Van Wart A, McCurry C, Yamamori T, Sur M. (2008). Gene expression patterns during the critical period: Synaptic stabilization and reversal by visual deprivation. Proc Natl Acad Sci 105(27): 9409-14.

Nishimune H, Valdez G, Miner JH, Sanes JR. (2008). Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction. J Cell Biol 182: 1201-15.

McDonald PW, Hardie SL, Jessen T, Carvelli L, Matthews D, Blakley R. (2007). Vigorous motor activity in Caenorhabditis elegans requires efficient clearance of dopamine mediated by synaptic localization of the dopamine transporter DAT-1. Journal of Neuroscience 27(51): 14216-27.

Kishida KT, Klann E. (2007). Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal 9(2): 233-44.

Hojjati, MR, van Woerden GM, Tyler WJ, Giese KP, Silva AJ, Pozzo-Miller L, Elgersma Y. (2007). Kinase activity is not required for aCaMKII-dependent presynaptic plasticity at hippocampal CA3-CA1 synapses. Nature Neuroscience 10(9): 1125-1127.

Argence M, Sáez I, Sassu R, Vassias I, Vidal PP, de Waele C. (2006). Modulation of inhibitory and excitatory synaptic transmission in rat inferior colliculus after unilateral cochleectomy: an in situ and immunofluorescence study. Neuroscience 141(3): 1193-207.

Kishida KT, Hoeffer CA, Hu D, Pao M, Holland SM, Klann E. (2006). Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease. Mol Cell Biol 26(15): 5908-20.

Li Z, Burrone J, Tyler WJ, Hartman KN, Albeanu DF, Murthy VN. (2005). Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin. Proceedings of the National Academy of Sciences 102(17): 6131-6136.

Tyler WJ, Murthy VN. (2004). Synaptic vesicles. Current Biology 14(8): R294-97.

Kalikulov D, Ayar A, Nuritova F, Frenguelli BG, McClelland Martin DJ, Davidson I, Scott RH. (2001). Venom from Anemesia species of spider modulates high voltage-activated Ca2+ currents from rat cultured sensory neurones and excitatory postsynaptic currents from rat hippocampal slices. Cell Calcium 30(3): 212-21.

King RD, Wiest MC, Montague PR. (2001). Extracellular calcium depletion as a mechanism for short-term synaptic depression. J. Neurophysiology 85(5): 1952-1959.

Berg-Johnsen J, Haugstad TS, Langmoen IA. (1998). Glutamate in the human brain: possible roles in synaptic transmission and ischemia. Progress in Brain Research 116: 287-302.

Person C, Egelman DM, King RD, Montague PR. (1996). Three-dimensional synaptic distributions influence neural processing through the resource consumption principle. Journal of Physiology (Paris) 90(5): 323-325.

Montague PR. (1995). Integrating information at single synaptic connections. Proceedings of the National Academy of Science 92: 2424-2425.

Montague PR, Sejnowksi TJ. (1994). The predictive brain: Temporal coincidence and temporal order in synaptic learning mechanisms. Learning and Memory 1(1): 1-33.