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Michelina Iacovino, PhD
The Role of HoxA3 During Hematopoietic Development
Research Assistant Professor, Pediatrics, Lillehei Heart Institute, University of Minnesota School of Medicine, Minneapolis, Minnesota
2 Riverside Circle, Roanoke, VA 24016
A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at 3 p.m., returning at 6 p.m.
Michelina Iacovino, PhD, will describe how Hox genes specify cell identity along the rostro-caudal axis during development, with particular emphasis on the role of Hox paralogs in the patterning of mesoderm with respect to hematopoiesis. She will present her recent findings on paralog group specific effects, such as the role of HoxA3 in the generation of hematopoietic stem cells.
- Iacovino M, Chong D, Szatmari I, et al. HoxA3 is an apical regulator of hemogenic endothelium. Nat Cell Biol, 2011, (1):72-8.
- Caprioli A, Koyano-Nakagawa N, Iacovino M, et al. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation, 2011, 123:1633-41.
About the Speaker:
Michelina Iacovino's research focuses on the molecular mechanisms of hematopoietic stem cell generation, and the role of Hox genes in normal and pathological development of the heart.