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Michelina Iacovino, PhD
The Role of HoxA3 During Cardiac Development
Research Assistant Professor, Pediatrics Lillehei Heart Institute University of Minnesota School of Medicine Minneapolis, Minnesota
2 Riverside Circle, Roanoke, VA 24016
A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at noon, returning at 2p.m.
Michelina Iacovino, PhD, will discuss her research plans for elucidating the role of HoxA3 expression at different stages of cardiac development, using an inducible gain of function approach. She will explore the interaction of HoxA3 with the Jag1-Notch signaling pathway and characterize the effect of HoxA3 deletion on cardiac precursors and differentiated cells. She will discuss how repressive signals generated by HoxA3 contribute to cardiac development and how perturbations to these signals lead to human cardiac disease.
Caprioli A, Koyano-Nakagawa N, Iacovino M, et al. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation, 2011, 123:1633–41.
About the Speaker:
Michelina Iacovino's research focuses on the molecular mechanisms of hematopoietic stem cell generation, and the role of Hox genes in normal and pathological development of the heart.