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Nilkantha Sen, PhD
Nitric Oxide/GAPDH/GOSPEL Cascade Regulates Beta Amyloid/Tau; Relevance to Alzheimer’s Disease
Research Associate, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD
2 Riverside Circle, Roanoke, VA 24016
A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at 3 p.m., returning at 6 p.m.
Alzheimer's disease (AD) is characterized by loss of neurons and buildup of plaques and tangles associated with accumulation of neurotoxic nitric oxide. A novel neuroprotective protein, GOSPEL, minimizes neurofibiliary tangle formation and up-regulates CREB function. GOSPEL levels are diminished in AD brain suggesting that drugs influencing GOSPEL disposition may be therapeutic.
- Sen N, Hara MR, Ahmad AS, et al. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron, 2009, 63: 81-91.
- Kornberg MD, Sen N, Hara, MR, et al., GAPDH mediates nitrosylation of nuclear proteins. Nature Cell Biology, 2010, 12:1094-100.
About the Speaker:
Nilkantha Sen's research focuses on the identification and development of novel molecular diagnostic and therapeutic biomarkers and targets for age related neurodegenerastion.