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Nilkantha Sen, PhD

Nilkantha Sen, PhD

Nitric Oxide/GAPDH/GOSPEL Cascade Regulates Beta Amyloid/Tau; Relevance to Alzheimer’s Disease


August 29, 2011, 4:00 p.m. to 5:00 p.m.


Nilkantha Sen, PhD

Research Associate, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD


Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016


A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at 3 p.m., returning at 6 p.m.

Alzheimer's disease (AD) is characterized by loss of neurons and buildup of plaques and tangles associated with accumulation of neurotoxic nitric oxide. A novel neuroprotective protein, GOSPEL, minimizes neurofibiliary tangle formation and up-regulates CREB function. GOSPEL levels are diminished in AD brain suggesting that drugs influencing GOSPEL disposition may be therapeutic.

Selected Publications

About the Speaker:

Nilkantha Sen's research focuses on the identification and development of novel molecular diagnostic and therapeutic biomarkers and targets for age related neurodegenerastion.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

This map shows where the Fralin Biomedical Research Institute is located in Roanoke, VA at 2 Riverside Circle.

Parking is available in the parking garage across the street.

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