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Nilkantha Sen, PhD
GOSPEL: A Novel Regulator of Tauopathy and CREB Signaling
Research Associate, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD
2 Riverside Circle, Roanoke, VA 24016
A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at noon, returning at 3 p.m.
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by global cognitive decline including progressive loss of memory, orientation and reasoning. Sen has identified GOSPEL as a novel neuroprotective protein. His future plans include efforts to elucidate mechanisms of GOSPEL function for the development of therapeutic applications.
- Sen N, Hara MR, Ahmad AS, et al., GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron, 2009, 63: 81-91.
- Kornberg MD, Sen N, Hara, MR, et al., GAPDH mediates nitrosylation of nuclear proteins. Nature Cell Biology, 2010, 12:1094-100.
About the Speaker:
Nilkantha Sen's research focuses on the identification and development of novel molecular diagnostic and therapeutic biomarkers and targets for age related neurodegenerastion.