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Michael B. Manookin

Michael B. Manookin

A retinal balancing act: crossover inhibition and NMDA receptors mediate visual sensitivity in parasol/M ganglion cells of the macaque monkey retina


June 9, 2011, 12:00 p.m. to 1:00 p.m.


Michael B. Manookin

Ph.D. is a postdoctoral fellow in the Department of Structural Biology at University of Washington in Seattle, WA


Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016

Michael Manookin, a postdoctoral fellow in the laboratory of Dennis Dacey at the University of Washington in Seattle, will present his recent findings from the macaque monkey retina on the role of a particular class of retinal ganglion cells in contributing to visual system sensitivity. Manookin uses a combination of electrophysiological, pharmacological and cellular structural analysis in the primate retina to functionally analyze the mechanisms that mediate changes in visual responsiveness over a range of visual conditions.

Manookin is a recent recipient of a prestigious Helen Hay Whitney Foundation Fellowship award.

Several recent publications of Manookin are listed below:

  • Crook JD, Manookin MB, Dacey DM. 2011. Non-synaptic horizontal cell feedback mediates ‘red-green’ color opponency in midget ganglion cells. J Neurosci, 31 (5):1762-72.
  • Manookin MB, Weick M, Stafford B, Demb JB. 2010. NMDA receptor contributions to visual contrast coding. Neuron, 67(2):280-293.\
  • Beaudoin DL, Manookin MB, Demb JB. 2008. Distinct expressions of contrast gain control in parallel synaptic pathways converging on a retinal ganglion cell. J Physiol 586(22):5487-5502.
  • Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB. 2008. Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight. J Neurosci 28(16):4136-50.
  • Zaghloul KA, Manookin MB, Borghuis BG, Boahen K, Demb JB. 2007. Functional circuitry for peripheral suppression in mammalian Y-type retinal ganglion cells. J Neurophysiol 97(6):4327-40.
  • Manookin MB, Demb JB. 2006. Presynaptic mechanism for slow contrast adaptation in mammalian retinal ganglion cells. Neuron 50(3):453-64.

About the Speaker:

Michael Manookin, Ph.D. is a postdoctoral fellow in the Department of Structural Biology at University of Washington in Seattle, WA.

Additional Details

This is a free event. The host is Michael Friedlander. For more information, please call 540-526-2013, or send an e-mail.

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