This event has already occurred.
Melanie Ohi, PhD
Taking a Combinatorial Approach to Understanding the Function of Macromolecular Machines
Assistant Professor of Cell and Developmental Biology, Vanderbilt University School of Medicine and Vanderbilt Ingram Cancer Center, Nashville, Tennessee
2 Riverside Circle, Roanoke, VA 24016
Proteins carry out most cellular processes as members of dynamic multi-protein assemblies. Although progress has been made in cataloging the constituents of specific complexes, we have only limited knowledge of how proteins assemble into macromolecular machines and how these machines perform their cellular functions. In this seminar, Melanie Ohi, PhD, will focus on using single-particle electron microscopy in combination with other biological and structural techniques to begin exploring how large macromolecular complexes perform their cellular functions.
About the Speaker:
Dr. Melanie Ohi is an assistant professor of cell and developmental biology at Vanderbilt University School of Medicine. There she uses yeast genetics, biochemistry, and single particle cryoelectron microscopy to explore the structural and functional organization of complexes involved in pre-mRNA splicing and complexes involved in the protein ubiquitination pathway. Dr. Ohi earned her doctorate in cell biology at Vanderbilt University before undertaking a postdoctoral fellowship at Harvard Medical School.