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Min Fang, PhD

Min Fang, PhD

Uncovering the Mechanisms of Natural Killer Cell–Mediated Resistance to a Viral Disease


October 3, 2011, 4:00 p.m. to 5:00 p.m.


Min Fang, PhD

Staff Scientist, Fox Chase Cancer Center, Philadelphia, Pennsylvania


Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016


A shuttle to Roanoke will depart from Blacksburg in front of Burruss Hall at 3 p.m., returning at 6 p.m.

Natural killer (NK) cells are innate effector cells serving as a first line of defense against certain viral infections. To date, only a few NK cell receptor–ligand interactions important for resistance to viral diseases have been identified. Ectromelia virus is an orthopoxvirus that causes mousepox, the murine equivalent of human smallpox. C57BL/6 (B6) mice are naturally resistant to mousepox due to the concerted action of innate and adaptive immune responses. The mechanisms of NK cell–mediated resistance have not been defined. Dr. Fang will present her findings showing that B6 mice resistance to mousepox requires the direct cytolytic function of NK cells to control early virus dissemination, and that the activating receptor NKG2D is required for optimal NK cell–mediated killing. These findings, along with the recent discovery of the loss of resistance to mousepox during aging in otherwise resistant mice, have implications for the understanding of natural resistance to pathogenic viral infections.

Selected Publications

About the Speaker:

Min Fang's research focuses on viral immunology, pathogenesis, and the mechanisms of vaccine protection during infection with ectromelia, an orthopoxvirus that causes mousepox.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

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Parking is available in the parking garage across the street.

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Event Type