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Yuzhi Chen, PhD
The Function of the Amyloid Precursor Protein and Its Implications in the Pathogenesis of Alzheimer’s Disease
Assistant Professor, Department of Geriatrics, Department of Neurobiology and Developmental Sciences, Reynolds Institute on Aging, The University of Arkansas for Medical Sciences, Little Rock, Arkansas
2 Riverside Circle, Roanoke, VA 24016
Alzheimer’s disease is the leading cause of dementia affecting millions of Americans. Dr. Chen’s research investigates how the normal physiological functions of the amyloid precursor protein (APP) and its proteolytic products are derailed in Alzheimer’s disease. She will present her results showing that APP interacts with the ubiquitination pathway and discuss how loss of Aβ40 may contribute to Alzheimer’s disease by affecting neurogenesis.
- Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL. APP-BP1 induced apoptosis and DNA synthesis and is increased in the Alzheimer’s diseased brain. J Cell Biology, 2003, 163: 27–33.
- Chen Y., Dong C. A beta 40 and A beta 42 affect cell fate decisions and cell cycle progression in neural precursor cells. Cell Death and Differentiation, 2009, 16:386–94.
About the Speaker:
Yuzhi Chen's research focuses on the roles of protein ubiquitination in Alzheimer’s disease and mental retardation.