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Yuzhi Chen, PhD
Dysfunction of Ubiquitination as a Potential Pathogenic Mechanism of Alzheimer’s Disease
Assistant Professor, Department of Geriatrics, Department of Neurobiology and Developmental Sciences, Reynolds Institute on Aging, The University of Arkansas for Medical Sciences, Little Rock, Arkansas
2 Riverside Circle, Roanoke, VA 24016
A major goal of Dr. Chen’s research is aimed at a molecular understanding the regulation of ubiquitination in neurons using both animal models and human tissue. She will discuss her future research plans investigating how the amyloid precursor protein interacts with the ubiquitination pathway, specifically through Cul5 and Cul4B ubiquitin ligases. She will also consider how downstream effectors may be targeted for disease interventions.
- Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL. APP-BP1 induced apoptosis and DNA synthesis and is increased in the Alzheimer’s diseased brain. J Cell Biology, 2003, 163: 27–33.
- Chen Y., Dong C. A beta 40 and A beta 42 affect cell fate decisions and cell cycle progression in neural precursor cells. Cell Death and Differentiation, 2009, 16:386–94.
About the Speaker:
Yuzhi Chen's research focuses on the roles of protein ubiquitination in Alzheimer’s disease and mental retardation.