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Zhi Sheng, PhD

Zhi Sheng, PhD

An Essential Survival Pathway in Malignant Glioma with Therapeutic Implications


September 6, 2011, 4:00 p.m. to 5:00 p.m.


Zhi Sheng, PhD

Postdoctoral Fellow, HHMI Laboratory, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts


Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016


A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at 3:00 p.m. and return at 6:00 p.m.

Dr. Sheng will present his work on malignant brain tumors (gliomas), using a genome-wide RNA interference screen that has led to the identification of a molecular pathway that regulates the transcription of activating transcription factor 5 (ATF5), one of the key regulators of glioma cell survival. This work has shown that ATF5 antagonizes apoptosis (programmed cell death) and increases the survival of the glioma cells through up-regulation of MCL1, a member of the anti-apoptotic BCL2 family. He will also discuss his findings on how ATF5 predicts a poor prognosis in malignant glioma and how targeting this essential survival pathway leads to significant inhibition of tumor growth in a mouse model of the disease.

Selected Publications

About the Speaker:

Dr. Sheng’s research focuses on molecular mechanisms of how glial cells in the brain become malignant, acquiring sustained proliferation capacity and escaping death, cancer specific autophagy-signaling pathways and glioblastoma-specific survival pathways.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

This map shows where the Fralin Biomedical Research Institute is located in Roanoke, VA at 2 Riverside Circle.

Parking is available in the parking garage across the street.

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Event Type