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Zhi Sheng, PhD
An Essential Survival Pathway in Malignant Glioma with Therapeutic Implications
Postdoctoral Fellow, HHMI Laboratory, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts
2 Riverside Circle, Roanoke, VA 24016
A shuttle van to Roanoke will depart from Blacksburg in front of Burruss Hall at 3:00 p.m. and return at 6:00 p.m.
Dr. Sheng will present his work on malignant brain tumors (gliomas), using a genome-wide RNA interference screen that has led to the identification of a molecular pathway that regulates the transcription of activating transcription factor 5 (ATF5), one of the key regulators of glioma cell survival. This work has shown that ATF5 antagonizes apoptosis (programmed cell death) and increases the survival of the glioma cells through up-regulation of MCL1, a member of the anti-apoptotic BCL2 family. He will also discuss his findings on how ATF5 predicts a poor prognosis in malignant glioma and how targeting this essential survival pathway leads to significant inhibition of tumor growth in a mouse model of the disease.
- Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nature Medicine, 2010, 16: 671-677.
- Sheng Z, Wang SZ, Green MR. Transcription and signaling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R. EMBO Journal, 2009, 28: 866-876.
About the Speaker:
Dr. Sheng’s research focuses on molecular mechanisms of how glial cells in the brain become malignant, acquiring sustained proliferation capacity and escaping death, cancer specific autophagy-signaling pathways and glioblastoma-specific survival pathways.