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Zhi Sheng, PhD
The Role of Autophagy in Glioblastoma
Postdoctoral Fellow, Howard Hughes Laboratory, Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts
2 Riverside Circle, Roanoke, VA 24016
A shuttle to Roanoke will depart from Blacksburg in front of Burruss Hall at 11 a.m., returning at 2 p.m.
Autophagy has been shown to be important in cancer formation and cancer therapeutic resistance. Dr. Sheng will discuss his future research plans for elucidating the role of autophagy in glioblastoma multiforme. He will consider how to elucidate the mechanisms that underpin the role of autophagy in the formation and therapeutic resistance of glioblastoma multiforme. This approach will be evaluated in the context of developing novel effective therapies. Three specific goals of Dr. Sheng’s future research plans will be presented and discussed: the characterization of genes that regulate autophagy in glioblastoma; the determination of the role of autophagy in the genesis of glioblastoma; and the elucidation of the role of autophagy in therapeutic resistance of glioblastoma.
- Sheng Z, Li L, Zhu LJ, Smith TW, Demers A, Ross AH, Moser RP, Green MR. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nature Medicine, 2010, 16: 671-677.
- Sheng Z, Wang SZ, Green MR. Transcription and signaling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R. EMBO Journal, 2009, 28: 866-876.
About the Speaker:
Dr. Sheng’s research focuses on molecular mechanisms of how glial cells in the brain become malignant, acquiring sustained proliferation capacity and escaping death, cancer specific autophagy-signaling pathways and glioblastoma specific survival pathways.