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Kelly Foster, PhD
Distinct Roles of NMDA Receptor Subunits in Long-Term Plasticity
Assistant Professor, Department of Neuroscience, Commonwealth Medical College, Scranton, Pennsylvania
2 Riverside Circle, Roanoke, VA 24016
NMDA receptors (NMDARs) play an intriguing and seemingly paradoxical role in cell signaling by stimulating opposing pathways under different conditions. For example, activation of NMDARs may result in either strengthening (long-term potentiation, or LTP) or weakening (long-term depression, or LTD) of synapses. Dr. Foster has demonstrated that NMDARs containing the GluN2B subunit support LTP while NMDARs containing the GluN2A subunit support LTD. Protein interactions with the intracellular C-terminal tails of these subunits, as opposed simply to differences in channel kinetics, contribute to this distinction.
Edbauer D, Neilson JR, Foster KA, et al. Regulation of synaptic structure and function by FMRP-associated MicroRNAs miR-125b and miR-132. Neuron, 2010, 65: 373–384.
Foster KA, McLaughlin N, Edbauer D, et al. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. J Neuroscience, 2010, 30: 2676–2685.
About the Speaker:
Kelly Foster's research focuses on identification of signaling pathways for cell survival in ischemic stroke damage during aging.