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Kelly Foster, PhD

Kelly Foster, PhD

Distinct Roles of NMDA Receptor Subunits in Long-Term Plasticity

When

September 12, 2011, 4:00 p.m. to 5:00 p.m.

Who

Kelly Foster, PhD

Assistant Professor, Department of Neuroscience, Commonwealth Medical College, Scranton, Pennsylvania

Where

Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016

NMDA receptors (NMDARs) play an intriguing and seemingly paradoxical role in cell signaling by stimulating opposing pathways under different conditions. For example, activation of NMDARs may result in either strengthening (long-term potentiation, or LTP) or weakening (long-term depression, or LTD) of synapses. Dr. Foster has demonstrated that NMDARs containing the GluN2B subunit support LTP while NMDARs containing the GluN2A subunit support LTD. Protein interactions with the intracellular C-terminal tails of these subunits, as opposed simply to differences in channel kinetics, contribute to this distinction.

Selected Publications

About the Speaker:

Kelly Foster's research focuses on identification of signaling pathways for cell survival in ischemic stroke damage during aging.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

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Event Type