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Kelly Foster, PhD
The Roles of NMDA Receptor Subunits and Associated Proteins in Excitotoxic Injury
Assistant Professor, Department of Neuroscience, Commonwealth Medical College, Scranton, Pennsylvania
2 Riverside Circle, Roanoke, VA 24016
Activation of NMDA receptors on neurons may result in either synaptic strengthening or weakening, while also contributing to neuroprotective and apoptotic pathways. Dr. Foster will discuss her plans to examine the signaling roles of the individual GluN2A and GluN2B NMDAR subunits in neuronal survival and proliferation following injury, as well as to identify proteins that interact with the subunits to mediate these responses. These proteins are potential targets for intervention following ischemic insult or traumatic brain injury.
Edbauer D, Neilson JR, Foster KA, et al. Regulation of synaptic structure and function by FMRP-associated MicroRNAs miR-125b and miR-132. Neuron, 2010, 65: 373–384.
Foster KA, McLaughlin N, Edbauer D, et al. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. J Neuroscience, 2010, 30: 2676–2685.
About the Speaker:
Kelly Foster's research focuses on identification of signaling pathways for cell survival in ischemic stroke damage during aging.