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Chun-An Chen, PhD
Redox Regulation of Endothelial Nitric Oxide Synthase and Cardiovascular Diseases
Research Scientist, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio
2 Riverside Circle, Roanoke, VA 24016
A VTCRI shuttle will depart from Burruss Hall in Blacksburg at 3:00 p.m. and return at 6:00 p.m.
Endothelial nitric oxide synthase (eNOS) is vital for regulating vascular function as it can produce both the vasodilator nitric oxide and the vasoconstrictor superoxide. S-glutathionylation of eNOS switches the enzyme from forming nitric oxide to forming superoxide. In hypertensive vessels, S-glutathionylation of eNOS is increased, and this is associated with impaired endothelium-dependent vasodilation. Oxidant stress occurs in many diseases, including heart attack, stroke, diabetes, and cancer. Dr. Chen will present his research on the identification and utilization of agents that reset this redox switch, thereby restoring normal nitric oxide synthase function with potential therapeutic value.
Chen C-A, Lin C-H, Druhan LJ, Wang T-Y, Chen Y-R, Zweier JL. Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation: a novel mechanism regulating eNOS function and coupling. J Biol Chem, 2011, 286, 29098–29107.
Chen C-A, Wang T-Y, Saradhadevi, V, et al. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature, 2010, 468, 1115–1118.
About the Speaker:
Chun-An Chen’s research focuses on redox regulation of eNOS and the dysfunction of redox regulatory enzymes in coronary heart disease.