This event has already occurred.

Chun-An Chen, PhD

Chun-An Chen, PhD

Redox Regulation of Endothelial Nitric Oxide Synthase and Cardiovascular Diseases


September 15, 2011, 4:00 p.m. to 5:00 p.m.


Chun-An Chen, PhD

Research Scientist, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio


Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016


A VTCRI shuttle will depart from Burruss Hall in Blacksburg at 3:00 p.m. and return at 6:00 p.m.

Endothelial nitric oxide synthase (eNOS) is vital for regulating vascular function as it can produce both the vasodilator nitric oxide and the vasoconstrictor superoxide. S-glutathionylation of eNOS switches the enzyme from forming nitric oxide to forming superoxide. In hypertensive vessels, S-glutathionylation of eNOS is increased, and this is associated with impaired endothelium-dependent vasodilation. Oxidant stress occurs in many diseases, including heart attack, stroke, diabetes, and cancer. Dr. Chen will present his research on the identification and utilization of agents that reset this redox switch, thereby restoring normal nitric oxide synthase function with potential therapeutic value.

Selected Publications

About the Speaker:

Chun-An Chen’s research focuses on redox regulation of eNOS and the dysfunction of redox regulatory enzymes in coronary heart disease.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

This map shows where the Fralin Biomedical Research Institute is located in Roanoke, VA at 2 Riverside Circle.

Parking is available in the parking garage across the street.

Click the "Google" logo for a larger version.

Event Type