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Chun-An Chen, PhD
Redox Regulation, Nitric Oxide Signaling, and Diseases
Research Scientist, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio
2 Riverside Circle, Roanoke, VA 24016
A VTCRI shuttle will depart from Burruss Hall in Blacksburg at 12:00 p.m. and return at 3:00 p.m.
Cardiovascular disease is a primary cause of death in the United States. Increased oxygen free radical generation, which can reduce the bioavailability of nitric oxide, is a primary trigger of pathogenesis in many cardiovascular diseases. In the endothelium, endothelial nitric oxide synthase (eNOS) is the enzyme that produces this critical molecule for maintaining normal cardiovascular function. Dr. Chen’s research has determined that eNOS can be oxidatively modified by S-glutathionylation, under oxidative stress. This modification can switch NOS from a nitric oxide producing enzyme to a superoxide generation enzyme. Dr. Chen will discuss his future research plans to investigate the mechanism of redox regulating enzymes, such as glutathione reductase, thioredoxin, and glutaredoxin, on the effects of NOS function as it pertains to cardiovascular disease.
Chen C-A, Lin C-H, Druhan LJ, Wang T-Y, Chen Y-R, Zweier JL. Superoxide induces endothelial nitric-oxide synthase protein thiyl radical formation: a novel mechanism regulating eNOS function and coupling. J Biol Chem, 2011, 286, 29098–29107.
Chen C-A, Wang T-Y, Saradhadevi, V, et al. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature, 2010, 468, 1115–1118.
About the Speaker:
Chun-An Chen’s research focuses on redox regulation of eNOS and the dysfunction of redox regulatory enzymes in coronary heart disease.