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Marc Vermulst, PhD

Marc Vermulst, PhD

A New Understanding of Mitochondrial Mutagenesis in Mice

When

September 20, 2011, 4:00 p.m. to 5:00 p.m.

Who

Marc Vermulst, PhD

Postdoctoral Research Scholar Department of Chemistry University of North Carolina, Chapel Hill

Where

Fralin Biomedical Research Institute, R1059
2 Riverside Circle, Roanoke, VA 24016

Notes:

A VTCRI shuttle will depart from Burruss Hall in Blacksburg at 3:00 p.m. and return at 6:00 p.m.

Mutations in mitochondrial DNA (mtDNA) are associated with numerous diseases that are endemic in Western society, including cancer, neurodegeneration, and diabetes. Dr. Vermulst will describe how a new experimental tool—the random mutation capture assay—can be used to detect mutations in the mitochondrial genome with unprecedented sensitivity. This tool allows for the first accurate determination of the mutation frequency and spectrum of the mitochondrial genome in mammals. It has also helped to quantify how DNA polymerase gamma, mitochondrial dynamics, and mitochondrial respiration affect the mutation rate. Dr. Vermulst will further discuss how much—or how little—mitochondrial mutations affect mammalian health.

Selected Publications

About the Speaker:

Marc Vermulst's research focuses on nongenetic mutations, single molecule analysis of errors in transcription, and translation in living cells during aging.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

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Parking is available in the parking garage across the street.

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Event Type