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Marc Vermulst, PhD
Mitochondrial Mutagenesis and Transcriptional Fidelity in Aging and Disease
Postdoctoral Research Scholar, Department of Chemistry, University of North Carolina, Chapel Hill
2 Riverside Circle, Roanoke, VA 24016
Dr. Vermulst will discuss how mitochondrial mutations can be used as markers for cell lineage tracing. Specifically, he will present two ways by which these mutations can be used to understand a variety of processes, including the natural history of cancers, tissue composition, and wound healing. He will also consider the impact of transcriptional and translational errors on the lifespan of cells by demonstrating a new tool he has developed that uses single molecule fluorescence to simultaneously measure genetic mutations, transcriptional errors, and translational errors in living cells. He will discuss his plans to use transgenic cells to understand how transcriptional errors in particular can affect the lifespan of cells and the sensitivity of cells to age-related diseases such as Alzheimer's and Parkinson's.
- Chen H, Vermulst M, Wang YE, et al. Mitochondrial fusion is required for mtDNA stability and tolerance of mtDNA mutations. Cell, 2010, 141: 280–289.
- Vermulst M, Wanagat J, Kujoth GC, et al. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nature Genetics, 2008, 40: 392–394.
About the Speaker:
Marc Vermulst's research focuses on non-genetic mutations, single molecule analysis of errors in transcription, and translation in living cells during aging.