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Rob Gourdie, PhD
Translating Lessons from Skin Wound Healing to Cardiac Anti-Arrhythmia Therapies
Board of Trustees’ Eminent Scholar, Professor of Regenerative Medicine and of Cell Biology, and Professor of Pediatric Cardiology, Medical University of South Carolina, Charleston, South Carolina
2 Riverside Circle, Roanoke, VA 24016
A VTCRI shuttle will depart from Burruss Hall in Blacksburg at 3:00 p.m. and return at 6:00 p.m.
Dr. Gourdie’s laboratory focuses on the gap junction protein connexin43 (Cx43). This research program encompasses both basic and translational approaches. In the basic studies, Dr. Gourdie and his team focus on cellular and molecular aspects of the carboxyl terminal domain of Cx43 in regulating signaling in the heart. In more translational and applied research, Dr. Gourdie and colleagues have developed drug discovery strategies using mimetic peptides that target functions of the Cx43 carboxyl terminus. In preclinical studies these peptides have been shown to have efficacy in promoting regenerative healing of skin wounds, reducing scar capsule formation around implants, and inhibiting cardiac scarring/arrhythmias following myocardial infarction. Dr. Gourdie's seminar will cover the dual basic/translational approach to research on Cx43 taken by his lab.
- Rhett JM, Jourdan J, Gourdie RG. Connexin 43 connexon to gap junction transition is regulated by zonula occludens-1. Molecular Biology Cell, 2011, 22: 1516–28.
- O'Quinn MP, Palatinus JA, Harris BS, Hewett KW, Gourdie RG. A peptide mimetic of the connexin 43 zonula occludens-1-binding domain reduces arrhythmias following cardiac injury. Circulation Research, 2011, 108: 704–715.
About the Speaker:
Rob Gourdie's research focuses on the induction of 3-D development of the coronary endothelium and stem cell origins of vasculature, conduction systems, cardiovascular wound healing, and diabetes.