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Amy Wagers, PhD
Reversing Stem Cell Dysfunction in Aging and Disease
Associate Professor of Stem Cell and Regenerative Biology, Harvard University; Principal Investigator, Joslin Diabetes Center; Early Career Scientist, Howard Hughes Medical Institute, Boston, Massachusetts
2 Riverside Circle, Roanoke, VA 24016
Stem cells are essential for tissue maintenance and repair after injury. Yet organismal aging leads to a loss of stem cell regenerative potential, which ultimately translates into a failure to maintain tissue homeostasis. Similarly, disruption of the normal balance between stem cell self-renewal and differentiation can lead to malignant transformation. This lecture will focus on strategies to intervene in these disease processes through an understanding of the intrinsic and extrinsic signals that control stem cell fate.
About the Speaker:
Amy Wagers received her doctorate in immunology and microbial pathogenesis from Northwestern University in 1999, and completed her postdoctoral fellowship at Stanford University School of Medicine. Since 2004, she has been a faculty member in the Section on Developmental and Stem Cell Biology at Joslin Diabetes Center and an associate professor of stem cell and regenerative biology at Harvard Medical School. Dr. Wagers is a recipient of the Burroughs Wellcome Fund Career Award in the Biomedical Science and the Smith Family New Investigator Award. Her current research is focused on defining the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming and muscle-forming stem cells.