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Steven Poelzing, PhD
How Many Cells Are Needed and How Close Do They Have to Be to Cause a Ventricular Arrhythmia?
Research Associate Professor, Department of Bioengineering, University of Utah, Salt Lake City, Utah
2 Riverside Circle, Roanoke, VA 24016
Sudden cardiac death presumably due to ventricular arrhythmias is a major cause of death. Ventricular arrhythmias require premature activity and conduction abnormalities. Dr. Poelzing will discuss the propensity and timing of premature activity and its dependence on intracellular sodium and calcium, investigating whether modulating intracellular sodium can affect the time to sodium-calcium exchange reversal, thereby coordinating a simultaneous trigger among thousands of cells. In addition, Dr. Poelzing will discuss his work on gap junctional uncoupling during cardiac disease that can produce conduction abnormalities, proposing that signal propagation occurs not only through gap junctions, but also by a non-gap junction mediated pathway that is co-localized at or near the gap junctions.