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Steven Poelzing, PhD

Steven Poelzing, PhD

Diabetes, Inflammation, and the Spread of Electricity in the Heart

When

May 18, 2012, 12:00 p.m. to 1:00 p.m.

Who

Steven Poelzing, PhD

Research Associate Professor, Department of Bioengineering, University of Utah, Salt Lake City, Utah

Where

Fralin Biomedical Research Institute, Room 1059, 2 Riverside Circle, Roanoke
2 Riverside Circle, Roanoke, VA 24016

Sudden cardiac death presumably due to ventricular arrhythmias is still a major cause of death. Ventricular arrhythmias can be precipitated by premature activity and conduction abnormalities. Dr. Poelzing’s group proposes that the propensity and timing of premature activity is in large part dependent on intracellular sodium as well as intracellular calcium. Sympathetic stimulation can exacerbate sodium and calcium handling, particularly during disease. Interestingly, diabetes modulates the heart’s response to sympathetic stimulation. Future research is aimed at understanding how diabetes affects sodium and calcium handling, and thereby premature activity during sympathetic stimulation. Once premature activity is initiated, it is thought to propagate from cell to cell via gap junctions. However, there is little agreement in the field on what degree of gap junctional uncoupling during disease is necessary to produce conduction abnormalities. Dr. Poelzing’s group recently provided evidence that the amount of fluid between cells can modulate propagation dependence on gap junction. They seek to understand how inflammatory signals, particularly in diabetes, modulate gap junctions, the extracellular matrix, and cardiac conduction.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2070, or send an e-mail.

Map and Parking

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