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Samy Meroueh, PhD
Chemical Probing Interactions of the Urokinase Receptor
Associate Professor of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana
2 Riverside Circle, Roanoke, VA 24016
Protein–protein interactions of the urokinase receptor, also known as uPAR, have been implicated in tumor invasion and metastasis. Dr. Meroueh’s laboratory employs a structure-based computational approach to identify small molecules that bind uPAR and modulate its protein interactions. This is followed by design, synthesis, and biochemical and cellular characterization of derivatives culminating in phosphoglycerate kinase and efficacy studies in a breast-to-lung metastasis orthotopic model.