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Samy Meroueh, PhD

Samy Meroueh, PhD

Chemical Probing Interactions of the Urokinase Receptor


November 2, 2012, 11:00 a.m. to 12:00 p.m.


Samy Meroueh, PhD

Associate Professor of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana


Fralin Biomedical Research Institute, 2 Riverside Circle, Roanoke
2 Riverside Circle, Roanoke, VA 24016

Protein–protein interactions of the urokinase receptor, also known as uPAR, have been implicated in tumor invasion and metastasis. Dr. Meroueh’s laboratory employs a structure-based computational approach to identify small molecules that bind uPAR and modulate its protein interactions. This is followed by design, synthesis, and biochemical and cellular characterization of derivatives culminating in phosphoglycerate kinase and efficacy studies in a breast-to-lung metastasis orthotopic model.

Additional Details

This is a free event. The host is Michael Friedlander, PhD. For more information, please call 540-526-2059.

Map and Parking

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