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Maximilian Muenke, MD
Holoprosencephaly and Fatty Liver: From Rare Diseases to Common Health Problems
Chief and Senior Investigator, Medical Genetics Branch; Head, Human Development Section; National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
2 Riverside Circle, Roanoke, VA 24016
The study of holoprosencephaly—a rare embryologic disorder affecting the forebrain—has helped our understanding of the etiology of nonalcoholic fatty liver in adulthood. Dr. Muenke will discuss the relationship of holoprosencephaly to fatty liver.
About the Speaker:
Dr. Muenke serves as the chief of the Medical Genetics Branch of the division of intramural research at the National Human Genome Research Institute, National Institutes of Health, and the director of the National Institutes of Health Medical Genetics and Genomic Medicine Residency and Fellowship programs. The focus of Dr. Muenke's laboratory research has been on the delineation and identification of the underlying causes of craniofacial anomalies in humans: craniosynostosis syndromes including the most common one, Muenke syndrome, and holoprosencephaly. More recently, their studies of the most common behavioral disorder of childhood, attention deficit hyperactivity disorder (ADHD), have led to the identification of ADHD and comorbid disorder susceptibility loci and genes. They are now generating genotypes on over 5,000 samples already available in the labr to define a genetics-symptoms-function-treatment predictive framework as a step towards personalized medicine in ADHD.