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Jeffrey Noebels, MD, PhD
Denial of Service Attacks: Network Hyperexcitability in Alzheimer’s Dementia [NOTE TIME CHANGE]
Professor of Neurology, of Neuroscience, and of Human Genetics; Cullen Trust for Health Care Endowed Chair; and Director of the Blue Bird Circle Developmental Neurogenetics Laboratory, Baylor College of Medicine, Houston, Texas
2 Riverside Circle, Roanoke, VA 24016
In this seminar, Dr. Noebels will discuss new evidence linking genes for Alzheimer’s dementia with abnormal cortical oscillations and clinically silent seizures in the temporal lobe. He will also examine the importance of recognizing and treating hippocampal network hyperexcitability to preserve cognitive function in the aging brain.
About the Speaker:
Jeffrey Noebels, MD, PhD, is a professor of neurology, neuroscience, and human and molecular genetics at Baylor College of Medicine. His laboratory focuses on identifying genes critical for normal cortical excitability and exploring the plasticity mechanisms underlying network synchronization disorders in the developing brain. In 1979, his laboratory discovered the absence epilepsy in the tottering mouse; since then, it has made pioneering discoveries involving the role of ion channels and genes using single locus mutations, leading to the development of more than 20 mouse models of monogenic epilepsies and the broad adoption of this research strategy in the analysis of epilepsy. He is also involved in translational research involving mouse models humanized by genetic engineering to express human disease mutations for several forms of neonatal seizure disorders. Dr. Noebels earned his PhD in neuroscience from Stanford University and his MD from the Yale University School of Medicine.