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Peter Kohl, MD, PhD
New Imaging Approaches for Cardiac Structure and Function
Professor and Chair of Cardiac Biophysics and Systems Biology, National Heart and Lung Institute, Imperial College London; Visiting Professor, Department for Computer Science, Oxford University, Oxford, England
2 Riverside Circle, Roanoke, VA 24016
Dr. Kohl’s research focuses on cardiac mechano-electric interactions. He will present novel imaging approaches, developed by his team and collaborators, to explore the crosstalk between these functions and myocardial structure. On the functional side, these range from low-cost instrumentation approaches for fluorescent mapping to space-encoded time domain recordings. For structure studies, approaches include live-heart diffusion tensor imaging, anatomical magnetic resonance imaging, and attempts to move toward a true 3-D histology.
About the Speaker:
Peter Kohl, MD, PhD, holds the chair in cardiac biophysics and systems biology at Imperial College London and is a visiting professor at the Department for Computer Science at the University of Oxford. He also is the deputy director of the Magdi Yacoub Institute in London. Dr. Kohl helped establish the concept that cardiac fibroblasts can make relevant contributions to the electro-mechanical integration of myocardium, including the discovery in situ of gap junctional coupling between fibroblasts and myocytes in native heart tissue (rabbit atrium). His lab currently works in mechano-electrical interactions and whole-heart integration, based on multi-modal/multi-resolution imaging across scales from subcellular levels to whole heart, combined with quantitative assessment of electro-mechanical interactions, and including the translation of conceptual to computational models. That approach has required the development of new imaging techniques, such as temporal pixel multiplexing, which allows one to obtain high-resolution stills and high-speed movies at the same time. The overall theme underlying Dr. Kohl’s research builds on the use of experimental and theoretical tools, to com¬bine reduction and integration, or what one might call systems biology of the heart. Dr. Kohl earned his MD and PhD from the Moscow Pirogov Institute.