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Terence S. Dermody, MD
How Viruses Infect the Brain
Dorothy Overall Wells Professor of Pediatrics and Pathology; Director, Division of Pediatric Infectious Diseases, Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, TN
2 Riverside Circle, Roanoke, VA 24016
Many pathogenic viruses can spread throughout the body to cause disease. However, the mechanisms that guide viruses from the site of primary infection to sites of secondary infection in various organs are not well understood. Dr. Dermody studies a particular class of these viruses called reoviruses to better understand how they replicate and the mechanisms they use to cause disease. In his public lecture, he will discuss how reovirus can disseminate through the bloodstream and infect the central nervous system. Remarkably, different components of the protein shell that surround the reovirus are used to engage specific receptors. This work identifies factors in the virus itself and in the host that regulate the spread of the infectious agent and the subsequent injury to the targeted organs such as the brain.
A public reception will precede this event in the VTC Cafe at 5 p.m.
About the Speaker:
Terence S. Dermody, MD, is the director of pediatric infectious diseases, the director of the medical scientist training program, and a professor of pediatrics at Vanderbilt University in Nashville, Tennessee. His laboratory studies the molecular pathogenesis of mammalian reovirus and Chikungunya virus infections. The research encompasses several interrelated themes to better understand viral and cellular mediators of disease, including the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. The laboratory is also developing viral vectors for oncolytic and vaccine applications. Dr. Dermody earned his medical degree from Columbia University and completed an internship and his residency at Presbyterian Hospital in New York City.