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Christopher S. Wilcox, MD, PhD
Oxidative Stress: The Prime Cause of Disease and Disability in the Second Half of Life? From Molecules to Models to Novel Medicines
Chief of Division of Nephrology & Hypertension; Director, Center for Hypertension, Kidney and Vascular Health, Georgetown University, Washington, DC
2 Riverside Circle, Roanoke, VA 24016
The seminar will open with a description of the definitions and biochemical processes that generate or metabolise reaction oxygen species, the genes involved and their expression in the cardiovascular and renal systems. Examples will then be discussed to illustrate the roles of oxidative stress in the development of hypertension and chronic kidney disease in rodent models and the new technology that permits direct experimental assessment. Next, studies will be reviewed of the results from human subjects to measure directly reaction oxygen species generation in their microvessels, and its role in later development of cardiovascular and kidney diseases. Finally, the development of a new, non-toxic, long-duration, orally active, antioxidant drug will be discussed and the problems for investigators in developing novel drugs will be reviewed.
About the Speaker:
Christopher S. Wilcox, MD, PhD, is the George E. Schreiner Chair of Nephrology, the Chief of the Division of Nephrology and Hypertension, and the director of the Hypertension, Kidney, and Vascular Research Center at Georgetown University.