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Helen Mayberg, MD
Mapping Depression Circuits: Foundation for New Treatment Strategies Using Deep Brain Stimulation [Brain School seminar]
Professor, Psychiatry, Neurology, and Radiology; Dorothy C. Fuqua Chair of Psychiatric Neuroimaging and Therapeutics; Emory University School of Medicine, Atlanta, Georgia; Member, NAS Institute of Medicine
2 Riverside Circle, Roanoke, VA 24016
Critical to the development of deep brain stimulation as a novel therapy for patients with treatment-resistant depression has been the further characterization of brain systems mediating normal and abnormal mood states as well as those mediating successful and unsuccessful response to various antidepressant interventions using functional neuroimaging. Building on converging evidence implicating the subcallosal cingulate as a critical node within an imaging-based, putative depression network model, the subcallosal cingulate white matter was targeted for initial proof-of-principle testing of deep brain stimulation in patients with treatment resistant major depression, adopting neuromodulation techniques routinely used to treat Parkinson’s disease and other movement disorders. The theoretical and data-driven foundation for this new treatment strategy as well as results from ongoing experimental studies will be presented.
A public reception will precede this event in the VTC Cafe at 5 p.m.
About the Speaker:
Helen S. Mayberg, MD, is a professor of psychiatry, neurology, and radiology, and the Dorothy C. Fuqua Chair of Psychiatric Neuroimaging and Therapeutics at the Emory University School of Medicine in Atlanta, Georgia. Dr. Mayberg heads a multidisciplinary depression research program dedicated to the study of brain circuits in depression and the effects of various antidepressant treatments, which are measured using a variety of functional and structural imaging tools. The primary focus of her laboratory is to development imaging and physiological-based algorithms that will discriminate between depressed patient subgroups and optimize the selection of treatment at all stages of the illness.
Dr. Mayberg received her bachelor's degree in psychobiology from the University of California, Los Angeles before earning her medical degree from the University of Southern California. She is a board-certified neurologist, trained at the Neurological Institute of New York at Columbia University, and completed a postdoctoral fellowship in nuclear medicine at the Johns Hopkins Medical Institutions.