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Mary E. Hatten, PhD
Mechanisms of Brain Development: Migration and Circuit Formation
Frederick P. Rose Professor
Director of the Laboratory of Developmental Neurobiology
Fellow, American Association for the Advancement of Science
New York, New York
2 Riverside Circle, Roanoke, VA 24016
Normal brain development involves the generation of young neurons, as well as their migration and assembly into neuronal layers. The process continues with the formation of synaptic connections between mature neurons to establish brain circuitry. Dr. Hatten studies the molecular control of these processes and how they relate to developmental disorders such as autism. She will discuss recent work on the genes that control neuronal migration, her discovery that pivotal changes occur in chromatin-modifying genes during circuit formation, and the role of the protein ASTN2 in synapse function and autism.