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Isabelle Deichendes, Ph.D.
Sodium Channels: From Bedside to Bench
Professor of Medicine, Physiology and Biophysics, and Biomedical Engineering
Case Western Reserve University
Director of Heart and Vascular Research Center
MetroHealth Medical Center
2 Riverside Circle, Roanoke, VA 24016
Dr. Deschenes's translational research focus on incomplete penetrance in inherited arrhythmias has allowed her to make fundamental findings on the sodium channel structure, assembly, and trafficking. She demonstrated that sodium channel proteins actually interact with each other, explaining the presence of sodium channel dominant-negative mutations in Brugada Syndrome. Until her seminal findings, sodium channels, unlike potassium channels, were thought to be a monomer working independently. She has demonstrated that sodium channel alpha-subunits actually form dimers with coupled gating properties. These findings have significant implication for all channelopathies.