Synaptic plasticity is widely considered to be a cellular mechanism underlying learning and memory. Intracellular calcium signaling plays a key role in the regulation of synaptic plasticity in many brains system. We previously showed that pairing of pre- and postsynaptic activity in layer 2/3 pyramidal neurons in visual cortex at a fixed temporal delay produces variable plasticity outcomes - long-term potentiation (LTP), long-term depression (LTD), or no change (NC) - in different cells. The major goal of my research is to determine whether these different plasticity outcomes are a function of the individual cell’s intracellular calcium signaling in response to the pairings.
Education and Training
- Institute of Biochemistry, Academy of Sciences of Uzbekistan: Ph.D. , Biophysics
- Baylor College of Medicine: Postdoctoral fellowship , Neuroscience