Sarika Srivastava

Sarika Srivastava, Ph.D.

Research Assistant Professor

Assistant Professor, Department of Internal Medicine, School of Medicine


Office phone: 540-526-2047

Office location: R3002

Email address:

Mitochondria are dynamic organelles central to energy production, metabolism, signaling and apoptosis. Proper mitochondrial function is critical for the maintenance of cellular energy and metabolic homeostasis as well as for the activation of appropriate stress responses. A major bioenergetic function of mitochondria is to produce ATP through a process of oxidative phosphorylation (OXPHOS). Mitochondrial dysfunction caused by genetic mutations that impair OXPHOS or energy production leads to a clinical onset of mitochondrial disease in which the high-energy-demanding tissues such as the nervous system, skeletal muscle and heart are predominantly affected. The estimated prevalence of mitochondrial disease is ~ 1:5,000. Mitochondrial dysfunction also increases with age and is associated with several age-related disorders including neurodegenerative diseases, metabolic syndrome and cancer. Currently, there is no cure for mitochondrial disease or dysfunction. Sirtuins are a family of NAD+-dependent protein deacetylases/mono-ADP-ribosyl transferases that have been implicated in the regulation of metabolic and energy homeostasis, stress responses, cell survival and aging. My research is focused on understanding how mammalian sirtuins impact mitochondrial bioenergetics, function and metabolism in healthy and disease states by employing a multi-disciplinary approach that involves biochemical, cell biological and mouse modeling experiments. The long-term goal of my research is to understand and identify novel signaling pathways that can improve mitochondrial dysfunction during disease and aging.

Research staff

  • Elina Kim, a member of the Virginia Tech Carilion School of Medicine class of 2023, is a medical student researcher mentored by Dr. Srivastava.

Education and Training

  • Harvard University: Postdoctoral fellowship , Cell Biology
  • University of Miami School of Medicine: Postdoctoral fellowship , Cell Biology
  • University of Miami School of Medicine: Ph.D. , Molecular Cell and Developmental Biology
  • Madurai Kamaraj University: M.S. , Biotechnology
  • Delhi University: B.S. , Botany

Previous Positions

  • Postdoctoral fellowship, Department of Cell Biology, Harvard Medical School

Awards and Honors

  • United Mitochondrial Disease Foundation Award, 2009-2011
  • Seahorse Bioscience Travel Award, 2014
  • Carilion Clinic Research Acceleration Program Grant Award, 2018-2019

Selected Publications

Srivastava S. (2019). Emerging Insights into the Metabolic Alterations in Aging Using Metabolomics. Metabolites 9(12): pii: E301. doi: 10.3390/metabo9120301.

McMillan RP, Stewart S, Budnick JA, Caswell CC, Hulver MW, Mukherjee K, Srivastava S. (2019). Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism. Scientific Reports 9(1).

Srivastava S. (2017). The mitochondrial basis of aging and age-related disorders. Genes (Basel) 8(12): pii: E398.