Aging Research Related

Events Related To Aging

The Aging Brain: Targeting Synapses to Prevent Cognitive Decline

March 14, 2019, 5:30 p.m. at Fralin Biomedical Research Institute

Gregorio Valdez, Ph.D.

Associate Professor, Fralin Biomedical Research Institute at VTC
Associate Professor, Biological Sciences, College of Science, Virginia Tech
Associate Professor of Internal Medicine, Virginia Tech Carilion School of Medicine

Brain School, Brain Awareness Week

Normal Aging vs. Dementia: What's Happening to Me?

March 14, 2019, 6 p.m. at Fralin Biomedical Research Institute

Brian Unwin, M.D.

Chief of Geriatrics and Palliative Medicine, Carilion Clinic

Brain School, Brain Awareness Week

Basic and Translational Studies on Inflammatory Pathways in the Aging Brain: Should We Fire the Janitor?

April 22, 2016, 1 p.m. at Fralin Biomedical Research Institute

Laura L. Dugan, MD

Abram C. Shmerling Professor of Alzheimer's and Geriatric Medicine; Head, Division of Geriatric Medicine, Department of Medicine; Vanderbilt Brain Institute and Neuroscience Program, Vanderbilt University School of Medicine

Timothy A. Johnson Medical Scholar Lecture Series

Learning, Memory, & The Aging Brain

March 16, 2016, 5:30 p.m. at Fralin Biomedical Research Institute

Rosalyn Moran

Brain School, Brain Awareness Week

Can We Live to 100? New Evidence from the National Institute on Aging

Dec. 10, 2015, 5:30 p.m. at Fralin Biomedical Research Institute

Marie A. Bernard, MD

Deputy Director
National Institute on Aging
National Institutes of Health
Bethesda, Maryland

Maury Strauss Distinguished Public Lectures

Cancer and Aging

May 22, 2014, 5:30 p.m. at Fralin Biomedical Research Institute

Ronald A. DePinho, MD

President, The University of Texas MD Anderson Cancer Center, Houston, TX; Member, U.S. National Academy of Sciences; Member, NAS Institute of Medicine

Maury Strauss Distinguished Public Lectures

Reversing Stem Cell Dysfunction in Aging and Disease

May 11, 2012, 1 p.m. at Fralin Biomedical Research Institute

Amy Wagers, PhD

Associate Professor of Stem Cell and Regenerative Biology, Harvard University; Principal Investigator, Joslin Diabetes Center; Early Career Scientist, Howard Hughes Medical Institute, Boston, Massachusetts

Maury Strauss Distinguished Public Lectures

Mitochondrial Mutagenesis and Transcriptional Fidelity in Aging and Disease

Sept. 21, 2011, 1 p.m. at Fralin Biomedical Research Institute

Marc Vermulst, PhD

Postdoctoral Research Scholar, Department of Chemistry, University of North Carolina, Chapel Hill

Special Seminars

Synaptic Effects of Aging and ALS From Cellular Phenomena to Molecular Analysis

Aug. 16, 2011, 1 p.m. at Fralin Biomedical Research Institute

Gregorio Valdez, PhD

Postdoctoral Fellow, Department of Molecular and Cellular Biology and the Center for Brain Science, Harvard University

Special Seminars

Cellular and Molecular Analysis of Aging: Disease-Afflicted and Regenerating Neuromuscular Synapses

Aug. 15, 2011, 4 p.m. at Fralin Biomedical Research Institute

Gregorio Valdez, PhD

Postdoctoral Fellow, Department of Molecular and Cellular Biology and the Center for Brain Science, Harvard University

Special Seminars

Stories Related To Aging

Scientists gain insight into the earliest changes that impair motor function during aging

March 9, 2018

A team of biomedical scientists led by Gregorio Valdez, an assistant professor at the Virginia Tech Carilion Research Institute, has found that the motor neurons responsible for controlling muscle movement ...

Resveratrol protects neuromuscular synapses, muscle fibers in aging mice

March 7, 2017

Virginia Tech Carilion Research Institute scientists have discovered that resveratrol, a compound in the skin of red grapes and red wine, and metformin, a drug often prescribed to fight type ...

Can 100 be the new average? Aging expert will discuss that prospect during the next public lecture

Dec. 1, 2015

Can we extend the average lifespan to a century? Marie Bernard, the deputy director of the National Institute on Aging will present new evidence to answer that question on December ...

President of nation’s top cancer hospital to speak on cancer and aging

May 14, 2014

With a talk on cancer and aging, Dr. Ronald DePinho, president of the University of Texas MD Anderson Cancer Center in Houston, will conclude the 2013–14 season of the Virginia ...

Growth factors could be key to warding off symptoms of amyotrophic lateral sclerosis and aging

Jan. 3, 2014

An early-career researcher at the Virginia Tech Carilion Research Institute has won his first major independent grant from the National Institutes of Health. And if his research pans out, the ...

Encouraging lifelong success through early reading

July 16, 2012

Sharon and Craig Ramey played instrumental roles in Roanoke's being named an All-America City for a record-breaking sixth time.

Brain imaging research reveals that physicians learn more by paying attention to failure

Nov. 23, 2011

Research led by Read Montague, director of the Human Neuroimaging Laboratory and the Computational Psychiatry Unit at the Virginia Tech Carilion Research Institute, reinforces the age-old idea that it’s important ...

Publications Related To Aging

Lee-Park JJ, Deshpande H, Lisinki J, LaConte S, Ramey SL, DeLuca S. (2018). Neuroimaging strategies addressing challenges in using fMRI for the children with cerebral palsy. Journal of Behavioral and Brain Science 8: 306-318.

Srivastava S. (2017). The mitochondrial basis of aging and age-related disorders. Genes (Basel) 8(12): pii: E398.

Taetzsch T, Tenga M, Valdez G. (2016). Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses During Aging and Progression of ALS. Journal of Neuroscience.

Hétu S, Luo Y, Saez I, D'Ardenne K, Lohrenz T, Montague PR. (2016). Asymmetry in Functional Connectivity of the Human Habenula Revealed by High-Resolution Cardiac-Gated Resting State Imaging. Human Brain Mapping 37(7): 2602-2615. doi: 10.1002/hbm.23194.

Dowalti E, Adams SE, Stiles AB, Moran RJ. (2016). Aging into perceptual control: A Dynamic Causal Modeling for fMRI study of bistable perception. Frontiers in Human Neuroscience 10.

GIlbert J, Symmonds M, Hanna MG, Dolan RJ, Friston KJ, Moran RJ. (2015). Profiling neuronal ion channelopathies with non-invasive brain imaging and dynamic causal models: Case studies of single gene mutations. Neuroimage 124: 43-53.

Legon W, Punzell S, Dowlatti E, Adams S, Stiles A, Moran RJ. (2015). Altered prefrontal excitation/inhibition balance and prefrontal output: markers of aging in human memory networks. Cerebral Cortex.

McClure SM, Bickel WK. (2014). A dual systems perspective on addiction: Contributions from neuroimaging and cognitive training. Annals of the New York Academy of Sciences.

Elerud C, Craddock RC, Fletcher S, Aulakh M, King-Casas B, Kuehl D, LaConte SM. (2014). Neuroimaging after mild traumatic brain injury: Review and meta-analysis. NeuroImage: Clinic 78(4): 335-348.

Pertsinidis A, Mukherjee K, Sharma M, Pang ZP, Park SR, Zhang Y, Brunger AT, Südhof TC, Chu S. (2013). Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proc Natl Acad Sci USA 110(30): E2812-20.

Dukes MJ, McDonald SM, Kelly DF. (2013). In situ molecular microscopy: imaging viruses in liquid at the nano-scale. Imaging and Microscopy.

Eklund A, Villani M, LaConte SM. (2013). Harnessing graphics processing units for improved neuroimaging statistics. Cogn Affect Behav Neurosci 13: 587-97.

Kishida KT, Montague PR. (2012). Imaging Models of Valuation During Social Interaction in Humans. Biological Psychiatry 72(2): 93-100. doi: 10.1016/j.biopsych.2012.02.037.

MacKillop J, Amlung MT, Wier LM, David SP, Ray LA, Bickel WK, Sweet LH. (2012). The neuroeconomics of nicotine dependence: A preliminary functional magnetic resonance imaging study of delay discounting of monetary and cigarette rewards in smokers. Psychiatry Res 202(1): 20-9.

Luo J, Wilson JD, Zhang J, Hirsch JI, Dorn HC, Fatouros PP, Shultz MD. (2012). A dual PET/MR imaging nanoprobe: 124I labeled Gd3N@C80. Applied Sciences 2(2): 465-78.

Valdez G, Tapia JC, Lichtman JW, Fox MA, Sanes JR. (2012). Shared resistance to aging and ALS in neuromuscular junctions of specific muscles. PLoS One 7(4): e34640.

Pan YA, Livet J, Sanes JR, Lichtman JW, Schier AF. (2011). Multicolor Brainbow imaging in zebrafish. Cold Spring Harbor Protocols 1.

McDonald SM, Patton JT. (2011). Assortment and packaging of the segmented rotavirus genome. Trends in Microbiology 19: 136-44.

Fillmore HL, Shultz MD, Henderson SC, Cooper P, Broaddus WC, Chen ZJ, Shu CY, Zhang J, Ge J, Dorn HC, Corwin F, Hirsch JI, Wilson J, Fatouros PP. (2011). Conjugation of functionalized gadolinium metallofullerenes with IL-13 peptides for targeting and imaging glial tumors. Nanomedicine 6(3): 449-58.

Shultz MD, Wilson JD, Fuller CE, Zhang J, Dorn HC, Fatouros PP. (2011). Metallofullerene-based nanoplatform for brain tumor brachytherapy and longitudinal imaging in a murine orthotopic xenograft model. Radiology 261: 136-43.

Shu C, Corwin FD, Zhang J, Chen Z, Reid JE, Sun M, Xu W, Sim JH, Wang C, Fatouros PP, Esker AR, Gibson HW, Dorn HC. (2009). Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivity. Bioconjugate Chemistry 20(6): 1186-93.

McClure SM, D’Ardenne K. (2009). Computational neuroimaging: monitoring reward learning with blood flow. In: Dreher JC, Tremblay L (Ed.), Handbook of Reward and Decision Making.

Shu C, Wang C, Zhang J, Gibson HW, Dorn HC, Corwin FD, Fatouros PP, Dennis TJS. (2008). Organophosphonate functionalized Gd@C82 as a magnetic resonance imaging contrast agent. Chemistry of Materials 20(6): 2106-109.

Shu CY, Ma XY, Zhang JF, Corwin FD, Sim JH, Zhang EY, Dorn HC, Gibson HW, Fatouros PP, Wang CR, Fang XH. (2008). Conjugation of a water-soluble gadolinium endohedral fulleride with an antibody as a magnetic resonance imaging contrast agent. Bioconjugate Chemistry 9(3): 651-5.

Z. Yang, S. LaConte, X. Weng, and X. Hu. (2008). Ranking and averaging independent component analysis by reproducibility (RAICAR). Hum Brain Mapp 29: 711–725.

Montague PR, King-Casas B, Cohen JD. (2006). Imaging valuation models in human choice. Annual Review of Neuroscience 29: 417-448.

Fatouros PP, Corwin FD, Chen ZJ, Broaddus WC, Tatum JL, Kettenmann B, Ge Z, Gibson HW, Russ JL, Leonard AP, Duchamp JC, Dorn HC. (2006). In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticle. Radiology 240(3): 756-64.

Pan YA, Misgeld T, Lichtman JW, Sanes JR. (2003). Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. Journal of Neuroscience 23: 11479-88.

Montague PR, Dayan P, Person C, Sejnowski TJ. (1995). Bee foraging in uncertain environments using predictive Hebbian learning. Nature 377: 725-728.
[COMMENTARY: The Bee's Needs] [PDF]

Montague PR, Dayan P, Person C, Sejnowski TJ. (1994). Foraging in an Uncertain Environment Using Predictive Hebbian Learning. Advances in Neural Information Processing Systems 6: 598-605.