Pearl Chiu, PhD
Assistant Professor, Virginia Tech Carilion Research Institute
Assistant Professor of Psychology, College of Science, Virginia Tech
Assistant Professor of Psychiatry and Behavioral Medicine, Virginia Tech Carilion School of Medicine
Research Program Summary
How is it that a depressed individual may value nothing at all, whereas an addict might value drug consumption at the expense of all else? What quantitative neurobehavioral measures of motivation, social function, and emotion may be useful for clinical assessment? What makes some people especially vulnerable to peer pressure?
To address these and related questions, the lab examines the neurobiology of human motivation and social decision-making. Our work focuses on how such processes may be perturbed and rehabilitated in psychiatric populations.
Ongoing projects use multiple converging methods (e.g., behavior, self-report, clinical interviews, computational models, fMRI) to: 1) identify neural circuitry involved in healthy decision-making; 2) specify how these pathways go awry in clinical populations marked by deficits in valuation and motivation (e.g., major depression, addiction, PTSD, autism); and 3) develop biologically-informed interventions to remediate these functional deficits.
For a full listing of Dr. Chiu's publications, visit PubMed.
Education and Training
- Baylor College of Medicine: Postdoctoral fellowship
- Harvard University: Ph.D., Psychology (Clinical Psychology, Experimental Psychopathology)
- Baylor College of Medicine
Assistant Professor, Neuroscience and Psychiatry
- Zhu L, Jenkins AC, Set E, Scabini D, Knight RT, Chiu PH, King-Casas B, Hsu M. (2014). Damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest. Nature Neuroscience.
- White SW, Mazefsky CA, Dichter GS, Chiu PH, Richey JA, Ollendick TH. (2014). Social-cognitive, physiological, and neural mechanisms underlying emotion regulation impairments: Understanding anxiety in autism spectrum disorder. International Journal of Developmental Neuroscience.
- King-Casas B, Chiu PH. (2012). Understanding interpersonal function in psychiatric illness through multiplayer economic games. Biol Psychiatry 72(2), 119-25.
- Tso IF, Chiu PH, King-Casas BR, Deldin PJ. (2011). Alterations in affective processing of attack images following September 11, 2001. J Trauma Stress 24(5), 538-45.
- Herman S, Archambeau OG, Deliramich AN, Kim BS, Chiu PH, Frueh BC. (2011). Depressive symptoms and mental health treatment in an ethnoracially diverse college student sample. J Am Coll Health 59(8), 715-20.
- Chiu PH, Lohrenz TM, Montague PR. (2009). Smokers' brains compute but ignore a fictive error signal in a sequential investment task. Nature Neuroscience 11, 514-520.
- Lindsey L, King-Casas B, Brovko J, Chiu PH. (2009). Toward functional neurobehavioral assessment of mood and anxiety. Conf Proc IEEE Engineering in Medicine and Biology, 5393-5396.
- Chiu PH, Holmes AJ, Pizzagalli DA. (2008). Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotional response inhibition. NeuroImage 42, 988-997.
- Chiu PH, Kayali MA, Kishida KT, Tomlin D, Klinger LG, Klinger M, Montague PR. (2008). Self responses along cingulate cortex reveal quantitative neural phenotype for high functioning autism. Neuron 57, 463-473.
- Chiu PH, Deldin PJ. (2007). Neural evidence for enhanced error detection in major depressive disorder. American Journal of Psychiatry 164, 608-616.